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Dosage must be adjusted in severe renal insufficiencyhigh doses may cause CNS toxicityincluding seizuressuperinfections and promotion of nonsusceptible organisms may occur with prolonged use or repeated therapy.
Cdifficile produces toxins A and B which contribute to the development of CDADHypertoxin producing isolates of Cdifficile cause increased morbidity and mortalityas these infections can be refractory to antimicrobial therapy and may require colectomyCDAD must be considered in all patients who present with diarrhea following antibiotic useCareful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
Anaphylactic/anaphylactoid reactionsincluding shock and fatalitiesskin rashesurticariadrug feverpruritusangioedemaand facial edemaErythema multiformeStevens-Johnson syndromeand serum sickness-like reactions have been reported.
Tonsillitis is a contagious infection with symptoms of bad breathsnoringcongestionheadachehoarsenesslaryngitis.
Continue to use this medication until the full prescribed amount is finishedeven if symptoms disappear after a few daysStopping the medication too early may allow bacteria to continue to growwhich may result in a relapse of the infection.
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