As prograf contains lactose, special care should be taken in patients with rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption.
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Liv tsts (sum alanin and aspatat aminotansass, alkalin phosphatas, and total biliubin) should b obtaind pitinitiating ACTOS. outin piodic monitoing liv tsts duing tatmnt with ACTOS is not commndd in patints without liv disas. Patints whhav liv tst abnomalitis pitinitiation ACTOS wha ound thav abnomal liv tsts whil taking ACTOS should b managd as dscibd und Wanings and Pcautions [s WANINGS AND PCAUTIONS and CLINICAL PHAMACOLOGY ].
Upp spiatoy tact inction, hadach, sinusitis, phayngitis, myalgia, dma, wight gain, hypoglycmia, dyspna; changs in sum lipids (may b bnicial), macula dma.
A dcas in th xposu pioglitazon and its activ mtabolits w notd with concomitant administation pioglitazon and topiamat [s CLINICAL PHAMACOLOGY ]. Th clinical lvanc this dcas is unknown; howv, whn ACTOS and topiamat a usd concomitantly, monitpatints adquat glycmic contol.
Pioglitazon hydochloid was not mutagnic in a batty gntic toxicology studis, including th Ams bactial assay, a mammalian cll owad gn mutation assay (CHO/HPT and AS52/XPT), an in vitcytogntics assay using CHL clls, an unschduld DNA synthsis assay, and an in vivmiconuclus assay.
Consquntly, ACTOS should not b usd in patints with activ bladd canc and th bnits glycmic contol vsus unknown isks canc cunc with ACTOS should b considd in patints with a pihistoy bladd canc.
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in addition to metoprolol, oral tablets also contain the following inactive ingredients cellulose compounds, magnesium stearate, titanium dioxide, polyethylene glycol, colloidal silicon dioxide, lactose, propylene glycol, talc, povidone, and sodium starch glycolate.
