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Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusionIn these patientsadministration of an NSAID may cause a dose-dependent reduction in prostaglandin formation andsecondarilyin renal blood flowwhich may precipitate overt renal decompensationPatients at greatest risk of this reaction are those with impaired renal functiondehydrationhypovolemiaheart failureliver dysfunctionthose taking diuretics and ACE inhibitors or ARBsand the elderlyDiscontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.
This medication may raise your blood pressureCheck your blood pressure regularly and tell your doctor if the results are high.
Before taking NSAIDStell your healthcare provider about all of your medical conditionsincluding if you:
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