The mean nevirapine auc0-24,ss and cmin,ss after 19 days of viramune xr dosing under fasted conditions were 82,000 ng hr ml and 2920 ng per ml, respectively.

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The available pharmacokinetic data suggest that the concomitant use of rifampicin and nevirapine is not recommendedFurthermorecombining the following compounds with Viramune is not recommendedefavirenzketoconazoledelavirdineetravirinerilpivirineelvitegravirin combination with cobicistatatazanavirin combination with ritonavirboceprevirfosamprenavirif not co-administered with low dose ritonavirsee section 4.5

The predetermined primary efficacy comparison was between the Viramune twice daily and the efavirenz treatment groups.

Risk of immune reconstitution syndrome if used in combination with other antiretroviral drugs.

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