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Tineapityriasisversicolor is a non-contagious infection of the skin caused by Pityrosporum orbiculareMalassezia furfurThis commensal organism is part of the normal skin floraIn susceptible individuals the condition is often recurrent and may give rise to hyperpigmented or hypopigmented patches on the trunk which may extend to the neckarms and upper thighsTreatment of the infection may not immediately result in restoration of pigment to the affected sitesNormalization of pigment following successful therapy is variable and may take monthsdepending on individual skin type and incidental skin exposureThe rate of recurrence of infection is variable.

Ketoconazole can prolong the QT intervalCo-administration of the following drugs with ketoconazole is contraindicateddofetilidequinidinepimozideand cisaprideKetoconazole can cause elevated plasma concentrations of these drugs which may prolong the QT intervalsometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointes.

Co-administration of the following drugs with ketoconazole is contraindicateddofetilidequinidinepimozidecisaprideKetoconazole can cause elevated plasma concentrations of these drugs and may prolong QT intervalssometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointesSee CONTRAINDICATIONSWARNINGSand PRECAUTIONSDRUG INTERACTIONS sections.

Patients should be instructed to report any signs and symptoms which may suggest liver dysfunction so that appropriate biochemical testing can be doneSuch signs and symptoms may include unusual fatigueanorexianausea and/or vomitingabdominal painjaundicedark urine or pale stoolssee WARNINGS section

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