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If your doctor directs you to take colchicine regularlyuse it regularly to get the most benefit from itTo help you remembertake it at the same time(seach day.
If you are taking colchicine to prevent gout attackscall your doctor right away if you experience a gout attack during your treatmentYour doctor may tell you to take an extra dose of colchicinefollowed by a smaller dose one hour laterIf you take extra doses of colchicine to treat a gout attackyou should not take your next scheduled dose of colchicine until at least 12 hours have passed since you took the extra doses.
No dedicated pharmacokinetic study has been conducted using colchicine capsules in patients with varying degrees of renal impairmentColchicine is known to be excreted in urine in humans and the presence of severe renal impairment has been associated with colchicine toxicityUrinary clearance of colchicine and its metabolites may be decreased in patients with impaired renal functionDose reduction or alternatives should be considered for the prophylaxis of gout flares in patients with severe renal impairmentColchicine is not effectively removed by hemodialysisPatients who are undergoing hemodialysis should be monitored carefully for colchicine toxicity.
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