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Symptom relief does not rule out the presence of other serious conditionsTalk with your doctor Talk to your doctor about serious side effectsincludingKidney problemsacute interstitial nephritismay happen at any time during treatment with NEXIUMCall your doctor if you have a decrease in the amount that you urinate or if you have blood in your urine NEXIUM may increase your risk of getting severe diarrheaCall your doctor right away if you have watery stoolstomach pain and fever that does not go away Bone fractures if you take multiple daily doses of NEXIUM for a year or longer Some people who take PPIsincluding NEXIUMdevelop certain types of lupus or have worsening of the lupus they already haveCall your doctor right away if you have joint pain or rash on your cheeks or arms that gets worse in the sun Low vitamin B12 if you have been on NEXIUM for a long timemore than 3 yearsLow magnesium levels if you take NEXIUMfor 3 months or moreTell your doctor about all of the medicines you takeprescription and nonprescription drugsincluding clopidogrelvitamins and herbal supplementsNEXIUM may affect how other medicines work and other medicines may affect how NEXIUM works Do not take NEXIUM if you are allergic to esomeprazole magnesium or any of the ingredients in NEXIUM or are allergic to any other PPI Side effects with NEXIUM may include headachediarrheaand abdominal pain.

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

You may be more likely to have a broken bone in your hipwristor spine while taking a proton pump inhibitor long-term or more than once per dayTalk with your doctor about ways to keep your bones healthy.

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at the end of the trial there was no significant difference between nexium 20 mg and omeprazole 20 mg in either healing or symptomatic relief of erosive esophagitis.