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Limited evidence suggests that Imuran is not beneficial to patients with hypoxanthine-guanine-phosphoribosyltransferase deficiencyLesch-Nyhan syndromeThereforegiven the abnormal metabolism in these patientsit is not prudent to recommend that these patients should receive Imuran.
Benefit versus risk must be weighed carefully before use of IMURAN in patients of reproductive potentialThere are no adequate and well-controlled studies in pregnant womenIf this drug is used during pregnancy or if the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard to the fetusWomen of childbearing age should be advised to avoid becoming pregnant.
If you’re taking Imurancall your doctor right away if you have any of these warning signs of infection:
Information is available on the risk of malignancy with the use of IMURAN in rheumatoid arthritissee ADVERSE REACTIONSIt has not been possible to define the precise risk of malignancy due to IMURANThe data suggest the risk may be elevated in patients with rheumatoid arthritisthough lower than for renal transplant patientsHoweveracute myelogenous leukemia as well as solid tumors have been reported in patients with rheumatoid arthritis who have received IMURAN.
In patients with renal and/or hepatic insufficiencydosages should be given at the lower end of the normal rangesee Special Warnings and Precautions for Use for further details
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