Fortunately for patients who need more relief, combining methotrexate with other medications will usually do the job, says dr.

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The good newsThese side effects can often be short-circuited by taking a folic acid supplementFolic acid is the synthetic form of folateOne study found that RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent.

Many drugs can interact with methotrexateThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed hereTell your doctor about all your current medicines and any medicine you start or stop using.

This medication may make you more sensitive to the sunLimit your time in the sunAvoid tanning booths and sunlampsUse sunscreen and wear protective clothing when outdoorsTell your doctor right away if you get sunburned or have skin blisters/redness.

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your doctor will order regular lab tests to check your response to methotrexate and monitor for toxicity.