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REVIA has been shown to produce complete blockade of the euphoric effects of opioids in both volunteer and addict populationsWhen administered by means that enforce complianceit will produce an effective opioid blockadebut has not been shown to affect the use of cocaine or other non-opioid drugs of abuse.
REVIA and its primary metabolite are excreted primarily in the urineand caution is recommended in administering the drug to patients with renal impairment.
There are no data that demonstrate an unequivocally beneficial effect of REVIA on rates of recidivism among detoxifiedformerly opioid-dependent individuals who self-administer the drugThe failure of the drug in this setting appears to be due to poor medication compliance.
In view of the lack of actual experience in the treatment of REVIA overdosepatients should be treated symptomatically in a closely supervised environmentPhysicians should contact a poison control center for the most up-to-date information.
If a more rapid transition from agonist to antagonist therapy is deemed necessary and appropriate by the healthcare providermonitor the patient closely in an appropriate medical setting where precipitated withdrawal can be managed.
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