Aprepitant, fosaprepitant major avoid the concomitant use of indinavir with aprepitant, fosaprepitant due to substantially increased exposure of aprepitant; increased indinavir exposure may also occur.

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Indinavir is metabolized by CYP3A4Drugs that induce CYP3A4 activity would be expected to increase the clearance of indinavirresulting in lowered plasma concentrations of indinavirCoadministration of CRIXIVAN and other drugs that inhibit CYP3A4 may decrease the clearance of indinavir and may result in increased plasma concentrations of indinavir.

It may also be necessary to avoid drugs that do not affect indinavir drug levelsbut cause similar side effects.

Cardiovascular Systemcardiovascular disorders including myocardial infarction and angina pectoriscerebrovascular disorder.

Hematologicincreased spontaneous bleeding in patients with hemophiliasee PRECAUTIONSacute hemolytic anemiasee WARNINGS

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indinavir may increase plasma concentrations of fluoxetine.