A keppra levetiracetam is a medication used to treat epilepsy and does list anxiety and nervousness as possible side effects.

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Potential pharmacokinetic interactions of or with levetiracetam were assessed in clinical pharmacokinetic studiesphenytoinvalproatewarfarindigoxinoral contraceptiveprobenecidand through pharmacokinetic screening in the placebo-controlled clinical studies in epilepsy patients.

A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetamExperimental data indicate that this binding site is the synaptic vesicle protein SV2Athought to be involved in the regulation of vesicle exocytosisAlthough the molecular significance of levetiracetam binding to SV2A is not understoodlevetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone miceThese findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.

KEPPRA can cause anaphylaxis or angioedema after the first dose or at any time during treatmentSigns and symptoms in cases reported in the postmarketing setting have included hypotensionhivesrashrespiratory distressand swelling of the facelipmoutheyetonguethroatand feetIn some reported casesreactions were lifethreatening and required emergency treatmentIf a patient develops signs or symptoms of anaphylaxis or angioedemaKEPPRA should be discontinued and the patient should seek immediate medical attentionKEPPRA should be discontinued permanently if a clear alternative etiology for the reaction cannot be establishedsee CONTRAINDICATIONS

The following adverse reactions are discussed in more details in other sections of labeling:

There have been isolated reports of decreased levetiracetam efficacy when the osmotic laxative macrogol has been concomitantly administered with oral levetiracetamThereforemacrogol should not be taken orally for one hour before and for one hour after taking levetiracetam.

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