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Epistaxis was generally self-limiting and mild in severityand occurred at a higher incidence compared to placebo5but at a comparable or lower incidence when compared to the active control nasal corticosteroids studiedup to 15as reported in clinical studies for allergic rhinitisThe incidence of all other adverse events was comparable with that of placeboIn patients treated for nasal polyposisthe overall incidence of adverse events was similar to that observed for patients with allergic rhinitis.
Efficacy and Safety studies of NASONEX Nasal Spray for the treatment of nasal polyposis were four months in duration.
Following 12 months of treatment with NASONEX Nasal Spray in a study of patients with perennial rhinitisthere was no evidence of atrophy of the nasal mucosaalsomometasone furoate tended to reverse the nasal mucosa closer to a normal histologic phenotypeNeverthelesspatients using NASONEX Nasal Spray over several months or longer should be examined periodically for possible changes in the nasal mucosaIf localised fungal infection of the nose or pharynx developsdiscontinuance of NASONEX Nasal Spray therapy or appropriate treatment may be requiredPersistence of nasopharyngeal irritation may be an indication for discontinuing NASONEX Nasal Spray.
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