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Promethazine suppositories are for rectal use onlyDo not try to swallow the suppositories or insert in any other part of your body.

PROMETHAZINE HYDROCHLORIDE TABLETS USP ARE CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGEsee WARNINGS-Black Box Warning and Use in Pediatric Patients

Rectal25 mg at bedtimeAlternatively12.5 mg may be administered before the evening meal and again at bedtime for antihistamine effects.

Atropine-like signs and symptomsdry mouthfixeddilated pupilsflushingas well as gastrointestinal symptomsmay occur.

Difficulty breathing slowed or stopped breathing dizziness lightheadedness fainting loss of consciousness fast heartbeat tight muscles that are difficult to move loss of coordination continuous twisting movements of the hands and feet dry mouth wide pupilsblack circles in the middle of the eyesflushing nausea constipation abnormal excitement or agitation nightmares.

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as promethazine hydrochloride is a rather strong sedating antihistamine, users are only allowed to use it for not more than seven days.