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In larger dosesfludrocortisone acetate inhibits endogenous adrenal cortical secretionthymic activityand pituitary corticotropin excretionpromotes the deposition of liver glycogenandunless protein intake is adequateinduces negative nitrogen balance.
The use of Florinef AcetateFludrocortisone Acetate Tablets USPin patients with active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimenIf corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivityclose observation is necessary since reactivation of the disease may occurDuring prolonged corticosteroid therapy these patients should receive chemoprophylaxis.
BECAUSE OF ITS MARKED EFFECT ON SODIUM RETENTIONTHE USE OF FLUDROCORTISONE ACETATE IN THE TREATMENT OF CONDITIONS OTHER THAN THOSE INDICATED HEREIN IS NOT ADVISED
Pregnancy and breastfeeding If you are pregnant or breastfeedingthink you may be pregnant or are planning to have a babyask your doctor or pharmacist for advice before taking this medicine.
Advise the patient to use the medicine only as directedto take a missed dose as soon as possibleunless it is almost time for the next doseand not to double the next dose.
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