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Because of the potassium-sparing properties of angiotensin-converting enzymeACEinhibitorsMAXZIDE should be used cautiouslyif at allwith these agentssee PRECAUTIONSDRUG INTERACTIONS
Any chloride deficit during thiazide therapy is generally mild and usually does not require any specific treatment except under extraordinary circumstancesas in liver disease or renal diseaseDilutional hyponatremia may occur in edematous patients in hot weatherappropriate therapy is water restrictionrather than administration of saltexcept in rare instances when the hyponatremia is life threateningIn actual salt depletionappropriate replacement is the therapy of choice.
To reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.
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