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Rizatriptan should be used with caution in dialysis patients due to a decrease in the clearance of rizatriptan.

The development of a potentially life-threatening serotonin syndrome may occur with triptansincluding rizatriptan treatmentparticularly during combined use with SSRIs or SNRIsIf concomitant treatment with rizatriptan and an SSRIe.gfluoxetineparoxetinesertralinefluvoxaminecitalopramescitalopramor SNRIe.gvenlafaxineduloxetineis clinically warrantedcareful observation of the patient is advisedparticularly during treatment initiation and dose increases or with addition of another serotonergic medicationSerotonin syndrome symptoms may include mental status changese.gagitationhallucinationsand comaautonomic instabilitye.gtachycardialabile blood pressureand hyperthermianeuromuscular aberrationse.ghyperreflexiaincoordinationand/or gastrointestinal symptomse.gnauseavomitingand diarrhoea

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The development of a potentially life-threatening serotonin syndrome may occur with triptansincluding rizatriptan treatmentparticularly during combined use with SSRIs or SNRIsIf concomitant treatment with rizatriptan and an SSRIe.gfluoxetineparoxetinesertralinefluvoxaminecitalopramescitalopramor SNRIe.gvenlafaxineduloxetineis clinically warrantedcareful observation of the patient is advisedparticularly during treatment initiation and dose increases or with addition of another serotonergic medicationSerotonin syndrome symptoms may include mental status changese.gagitationhallucinationsand comaautonomic instabilitye.gtachycardialabile blood pressureand hyperthermianeuromuscular aberrationse.ghyperreflexiaincoordinationand/or gastrointestinal symptomse.gnauseavomitingand diarrhoea

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rizatriptan increases blood pressure; therefore, rizact tablets should not be given to patients with uncontrolled hypertension.