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Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone productsThese include urticariapruritusskin rashflushingangioedemavarious GI symptomsabdominal painnauseavomiting and diarrheafeverarthralgiaserum sickness and wheezingHypersensitivity to levothyroxine itself is not known to occur.
If this condition is treateda lower levothyroxine sodium dosee.g1 mcg/kg/daythan that used for full replacement may be adequate to normalize the serum TSH levelPatients who are not treated should be monitored yearly for changes in clinical status and thyroid laboratory parameters.
In patients with severe hypothyroidismthe recommended initial levothyroxine sodium dose is 12.5-25 mcg/day with increases of 25 mcg/day every 2-4 weeksaccompanied by clinical and laboratory assessmentuntil the TSH level is normalized.
In the treatment of well-differentiatedpapillary and follicularthyroid cancerlevothyroxine is used as an adjunct to surgery and radioiodine therapyGenerallyTSH is suppressed to.
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