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Letrozole is a drug used as hormone therapy for the treatment of breast cancerand included in a group of drugs called aromatase inhibitors due to its mechanism of actionEstrogen and progesterone are female sex hormones that promote cancer growthWhile in menstruating womenthese hormones are produced in the ovariesin menopausal womenit is produced in the fat tissue through a process known as aromataseThereforeletrozole interferes with this process in order to decrease the levels of estrogen in the body andconsequentlystop or slow down cancer growthor decrease the probability of cancer recurrence after surgeryLetrozole is only effective in hormone sensitive or hormone receptor positive breast cancer and its use is limited to women after menopause.

The CHMPin light of the data submitted and the scientific discussion within the Committeewas of the opinion that the SmPCslabelling and package leaflets should be harmonised across the EU.

In postmenopausal womenAdjuvant treatment of hormone receptor positive early breast cancerExtended adjuvant treatment of early breast cancer after 5 years of adjuvant tamoxifen therapyFirst-line treatment of hormone receptor positive or unknownlocally advanced or metastatic breast cancerTreatment of advanced breast cancer with disease progression following antiestrogen therapy.

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