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Dipyridamole inhibits phosphodiesterasePDEin various tissuesWhile the inhibition of cAMP-PDE is weaktherapeutic levels of dipyridamole inhibit cyclic-35guanosine monophosphate-PDEcGMP-PDEthereby augmenting the increase in cGMP produced by EDRFendothelium-derived relaxing factornow identified as nitric oxide

Adverse reactions at therapeutic doses are usually minimal and transientOn long-term use of Persantinedipyridamole USPtablets initial side effects usually disappearThe following reactions in Table 1 were reported in two heart valve replacement trials comparing PersantinedipyridamoleE tablets and warfarin therapy to either warfarin alone or warfarin and placebo:

Unless your doctor tells you otherwisecontinue your normal diet while taking aspirin and extended-release dipyridamole.

Persantinedipyridamole USPtablets have been found to lengthen abnormally shortened platelet survival time in a dose-dependent manner.

Persantinedipyridamole USPtablets have been found to lengthen abnormally shortened platelet survival time in a dose-dependent manner.

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