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RareAngioedemaerythemaexfoliative dermatitisfungal dermatitisherpes zosterleukodermamultiforme erythemapetechial rashpustular rashStevens-Johnson syndromevesiculobullous rash.

Other than agethere are as yet no factors identified that are known to predict the risk of occurrence or the severity of rash caused by LAMICTALThere are suggestionsyet to be proventhat the risk of rash may also be increased by1coadministration of LAMICTAL with valproateincludes valproic acid and divalproex sodium2exceeding the recommended initial dose of LAMICTALor3exceeding the recommended dose escalation for LAMICTALHowevercases have occurred in the absence of these factors.

The elimination half-life and apparent clearance of lamotrigine following oral administration of LAMICTAL to adult subjects with epilepsy and healthy volunteers is summarized in Table 14Half-life and apparent oral clearance vary depending on concomitant AEDs.

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